Nutrient ListNutrient List
Based on the Seven Physiological Imbalances Framework of Functional Medicine · Pathway-Collaborative Compound Design · Clinically Supported EvidenceFM Tree Framework · Pathway Synergy · Clinical Evidence
AKK bacteria
Akkermansia muciniphila
AKK surface protein Amuc-1100 upregulates intestinal tight junction proteins (ZO-1, Occludin) via the TLR2 receptor, repairing leaky gut and improving metabolic health.
Tributyrin
Tributyrin
Butyrate precursor that directly nourishes colon epithelial cells, promotes tight junction protein synthesis, and delivers dual intervention with Akkermansia muciniphila: barrier repair + cellular nutrition.
L-Glutamine
L-Glutamine
Primary energy source for enterocytes; promotes intestinal mucosal repair and supports tight junction protein synthesis.
Compound Digestive Enzymes
Digestive Enzyme Complex
Broad-spectrum enzyme coverage for the digestion of all three macronutrients: proteases break down proteins, lipases break down fats, and amylases break down carbohydrates.
psyllium husk
Psyllium Husk
Soluble dietary fiber absorbs water, swells to form a gel-like substance, promotes bowel motility, and serves as a fermentation substrate for beneficial bacteria to produce short-chain fatty acids.
Zinc Carnosine
Zinc Carnosine (Polaprezinc)
Zinc and L-carnosine complex that specifically adheres to damaged gastric mucosa, promotes mucosal repair, and inhibits Helicobacter pylori activity.
Aloe Juice Extract
Aloe Vera Juice Extract
Contains polysaccharides (acetylated mannan) with anti-inflammatory and mucosal repair properties to soothe gastrointestinal irritation and promote proliferation of intestinal epithelial cells.
Berberine (Intestinal Antibacterial)
Berberine (Antimicrobial)
Natural plant alkaloids with broad-spectrum antimicrobial activity. Inhibits the proliferation of pathogenic bacteria (E. coli, S. aureus) without disrupting beneficial microbiota.
High Bioavailability Curcumin
Curcumin (High Bioavailability)
Inhibits NF-κB and COX-2 pathways for potent anti-inflammatory effects. Phospholipid complex/nanomicelle technology increases bioavailability by 2000%.
Ergothioneine
L-Ergothioneine
The only antioxidant with a dedicated transporter (OCTN1), it specifically accumulates in mitochondria to protect mtDNA from oxidative damage.
Omega-3 fatty acids
Omega-3 Fatty Acids (EPA/DHA)
EPA/DHA converts into resolvins and protectins, actively promoting the resolution of inflammation rather than simply suppressing it.
Liposomal Glutathione
Liposomal Glutathione
The body's "master antioxidant," involved in detoxification (Phase II conjugation), immune modulation (T-cell function), and protection of protein sulfhydryl groups. Liposomal technology enhances bioavailability.
NAC (N-acetylcysteine)
N-Acetyl Cysteine
Glutathione precursor that supplies cysteine (the rate-limiting step in GSH synthesis) and exhibits mucolytic and heavy metal chelating activity.
Elderberry Extract
Elderberry Extract (Sambucus nigra)
Rich in anthocyanins and polyphenols, it inhibits viral hemagglutinin activity to block viral entry into host cells while stimulating cytokine production to enhance immune response.
Vitamin D3
Vitamin D3 (Cholecalciferol)
Modulates Treg cell differentiation, inhibits excessive Th17 activation, and maintains the balance between immune tolerance and defense. The vitamin D receptor (VDR) is widely expressed in immune cells.
Quercetin
Quercetin
Natural flavonoids that inhibit mast cell degranulation (reducing histamine release), regulate Th1/Th2 balance, and act as zinc ionophores to promote cellular zinc uptake.
Silybin
Silymarin (Milk Thistle)
Stabilizes hepatocyte membranes, regulates CYP450 enzyme activity (maintains Phase I detoxification efficiency), provides antioxidant protection to hepatocytes, and promotes hepatocyte regeneration.
Phase II substrates (glycine + taurine)
Glycine + Taurine
Facilitates Phase II conjugation reactions—including glucuronidation, sulfation, and glutathione conjugation—to convert highly reactive intermediates generated in Phase I into harmless, water-soluble substances.
Chlorella
Chlorella
Natural heavy metal chelator that promotes the elimination of lead, mercury, arsenic, and other heavy metals while providing chlorophyll and essential micronutrients.
Alpha-Lipoic Acid
Alpha-Lipoic Acid (ALA)
Universal antioxidant with both water- and fat-soluble properties; regenerates vitamins C, E, and glutathione. Part of the pyruvate dehydrogenase complex, linking glucose metabolism with detoxification pathways.
Dandelion Root Extract
Dandelion Root Extract
Promotes bile secretion and flow (cholagogic effect), supports hepatic fat metabolism, and contains inulin as a prebiotic for beneficial gut bacteria.
Calcium gluconate
Calcium D-Glucarate
Inhibits β-glucuronidase activity to prevent the re-hydrolysis and reabsorption of conjugated toxins in the gut (enterohepatic circulation), promoting their final elimination.
Activated Carbon
Activated Charcoal
Ultra-high specific surface area (500-1500 m²/g) physically adsorbs intestinal endotoxins, drug residues, and metabolic waste to prevent their absorption.
Sulforaphane
Sulforaphane
Activate the Nrf2 pathway (the master antioxidant switch in cells) to upregulate phase II detoxification enzymes (GST, NQO1, HO-1), enhancing the cell's intrinsic detoxification capacity.
NMN (β-Nicotinamide Mononucleotide)
NMN (β-Nicotinamide Mononucleotide)
NAD+ direct precursor, converted to NAD+ via NMNAT enzymes. NAD+ participates in 500 enzymatic reactions; its decline with age is a core mechanism of aging.
PQQ (pyrroloquinoline quinone)
PQQ (Pyrroloquinoline Quinone)
One of the most potent activators of mitochondrial biogenesis, promoting new mitochondria formation by activating the CREB and PGC-1α pathways.
Panthenol CoQ10
Ubiquinol (Reduced CoQ10)
CoQ10 (Reduced Form), a key cofactor in the electron transport chain. Ubiquinol offers 3-8 times higher bioavailability than ubiquinone, suitable for individuals aged 40 and above.
Berberine
Berberine
Activate the AMPK pathway (cellular energy sensor) to improve insulin sensitivity and regulate lipid metabolism.
Acetyl-L-carnitine
Acetyl-L-Carnitine (ALCAR)
Transports long-chain fatty acids to the mitochondrial matrix for β-oxidation to generate energy, while supplying acetyl groups for acetylcholine synthesis—supporting both energy production and cognitive function.
Monohydrate Creatine
Creatine Monohydrate
Stored as phosphocreatine in muscle and brain tissue, it rapidly regenerates ATP (ATP-PCr system) to provide immediate energy buffering for high-intensity exercise and cognitive tasks.
R-lipoic acid
R-Alpha Lipoic Acid
The natural R-isomer of lipoic acid serves as a cofactor for pyruvate dehydrogenase and α-ketoglutarate dehydrogenase, directly participating in mitochondrial energy metabolism.
Resveratrol
Resveratrol (Trans-)
Activates SIRT1 (longevity deacetylase) to mimic calorie restriction, promoting mitochondrial biogenesis and autophagy while protecting cardiovascular health.
Ashwagandha KSM-66
Ashwagandha KSM-66
Adaptogenic herbs: Withanolides A and D mimic GABAergic inhibition, reduce HPA axis hyperactivation, and regulate cortisol rhythm.
Inositol (Myo/D-chiro 40:1)
Inositol (Myo/D-chiro 40:1)
MI promotes GLUT4 translocation to the cell membrane, improving insulin sensitivity. DCI enhances glycogen synthesis and the conversion of androgens to estrogens. 40:1 mimics physiological plasma ratios in the human body.
5-HTP (5-hydroxytryptophan)
5-HTP (5-Hydroxytryptophan)
Direct serotonin precursor that crosses the blood-brain barrier to convert into serotonin (5-HT), regulating mood, sleep, and appetite.
Selenium (Selenomethionine)
Selenium (Selenomethionine)
Cofactor for iodothyronine deiodinases, involved in T4→T3 conversion (thyroid hormone activation), and an essential component of glutathione peroxidase (GPx).
Phosphatidylserine
Phosphatidylserine (PS)
Key phospholipid component of cell membranes; buffers HPA axis overactivation (reduces post-exercise cortisol spikes); supports neuronal membrane fluidity and synaptic signal transmission.
L-Tyrosine
L-Tyrosine
Precursor amino acids for dopamine, norepinephrine, and epinephrine; supplementation under stress helps maintain neurotransmitter levels to support focus and stress adaptation.
DIM (Diindolylmethane)
DIM (Diindolylmethane)
Metabolite of indole-3-methanol found in cruciferous vegetables; promotes conversion of estrogen to beneficial metabolites (2-OHE1) and inhibits harmful metabolites (2α-OHE1).
Rhodiola Extract
Rhodiola Rosea Extract
Adaptogenic herbs, rosavin, and tyrosol regulate the HPA axis and sympathetic nervous system to enhance stress resilience, reduce fatigue, and improve focus.
Vitamin K2 (MK-7)
Vitamin K2 (MK-7)
Activates osteocalcin to direct calcium to bones and activates matrix Gla protein (MGP) to prevent vascular calcification. The "Calcium Navigator."
Hydrolyzed Collagen
Collagen Peptides (Hydrolyzed)
Hydrolyzed into small-molecule peptides (2000-5000 Da). After absorption, they selectively accumulate in cartilage tissue and stimulate chondrocytes to synthesize ECM (extracellular matrix).
HMB (beta-hydroxy beta-methylbutyrate)
HMB (β-Hydroxy-β-Methylbutyrate)
Leucine metabolites reduce muscle protein breakdown (by inhibiting the ubiquitin-proteasome pathway) and promote muscle protein synthesis.
Magnesium Citrate
Magnesium Citrate
Magnesium is a key component of the bone mineral matrix (accounting for 60% of total bone magnesium) and plays a role in vitamin D activation, parathyroid hormone regulation, and osteoblast function.
Boron
Boron (Boron Citrate)
Extends the half-life of vitamin D and estrogen, enhances calcium, magnesium, and phosphorus utilization for bone health, and supports bone mineralization and joint wellness.
Glucosamine + Chondroitin
Glucosamine + Chondroitin
Glucosamine is a precursor for glycosaminoglycans (GAGs) in cartilage matrix, while chondroitin inhibits cartilage-degrading enzymes (MMPs). Together, they synergistically support joint cartilage repair.
MSM (Dimethyl Sulfone)
MSM (Methylsulfonylmethane)
Organic Sulfur Donor: Sulfur is a key structural element in collagen, chondroitin, and keratin. MSM provides bioavailable sulfur to support connective tissue synthesis.
Silicon (silicone)
Silica (Organic Silicon)
Silicon is an essential trace element required for collagen cross-linking and bone mineralization. It promotes osteoblast activity and supports the structural integrity of bones, skin, and connective tissues.
Extended-Release Melatonin
Melatonin (Extended-Release)
A circadian rhythm-regulating hormone secreted by the pineal gland. Sustained-release technology mimics the physiological secretion curve: an immediate-release layer aids sleep onset, while a sustained-release layer maintains sleep throughout the night.
L-Theanine
L-Theanine
Promotes alpha brain wave production to enhance focus while maintaining relaxation. Regulates GABA and dopamine levels without causing drowsiness.
SAMe (S-adenosylmethionine)
SAMe (S-Adenosylmethionine)
The body's most critical methyl donor, participating in 100+ methylation reactions—including neurotransmitter synthesis, DNA methylation, phospholipid metabolism, and homocysteine metabolism.
Magnesium Glycinate
Magnesium Glycinate
Magnesium glycinate offers high bioavailability. Glycine lowers core body temperature to promote sleep, while magnesium ions regulate NMDA receptors to reduce nighttime awakenings.
GABA (γ-aminobutyric acid)
GABA (Gamma-Aminobutyric Acid)
A major inhibitory neurotransmitter in the central nervous system; activates GABA-A receptors to produce sedative and anxiolytic effects by reducing excessive neuronal excitation.
Lion's Mane Extract
Lion's Mane Mushroom (Hericium erinaceus)
Contains hericenones and erinacines from lion's mane mushroom, which stimulate nerve growth factor (NGF) synthesis to promote neuronal growth and synaptic plasticity.
Bengal dayflower extract
Bacopa Monnieri Extract
Contains bacosides, enhances synaptic signal transmission (acetylcholinesterase inhibition), promotes dendritic branching, and improves memory consolidation.
Magnesium L-Threonate
Magnesium L-Threonate
The only proven magnesium form that effectively crosses the blood-brain barrier, significantly boosting brain magnesium levels, enhancing synaptic density and plasticity, and improving learning and memory.
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